A well-designed/performed, double-blind, randomized, placebo-controlled trial provides a high level of certainty about the effectiveness of an intervention. In scientific training, the need to utilize a placebo relative to your variable of interest is one of the first things you learn when designing an experiment. As many in the basic sciences and evidence-based medicine fields have become more interested in nutrition and its impact on health/biology (their interest is well-justified), there has been insufficient appreciation for the difficulty in performing nutrition research. This day 1 principle of "placebo-controlled" poses a particular challenge for many nutrition experiments: there is no placebo. Consider an example that actually plagued causal inference in nutrition history: It was known that feeding diets high in saturated fatty acids was associated with higher LDL. Does that mean that saturated fat raises LDL? How would you design a study to show
The prestigious Mayo Clinic regularly gets itself into hot water across evidence-based medicine and skeptics circles (see here ) for its heavy promotion of questionable science; Mayo is particularly entrenched in the complementary/alternative/integrative/functional medicine (CAM/IFM) movement that is taking academic medical centers by storm (it even has a peer reviewed publication about its CAM use). Mayo, like other famous clinics, seems more than happy to promote its clinic with low-to-no evidence modalities that have been re-branded under the CAM/IFM movement. There's a nutrition video that Mayo has produced and is circulating around the social media spheres. I've seen it before but today it made me particularly annoyed so here we are. The video covers the role of a whole foods plant-based diet as 'powerful medicine' with a focus on cancer. You can see the video embedded below. A link to their tweet with the video can be found here and its also up on their YouTub